On Leptospirosis and its Epidemiology
An update on current knowledge and Public Health Challenges
DOI:
https://doi.org/10.56226/90Keywords:
Epidemiology, Public Health, LeptospirosisAbstract
Leptospirosis has been known to affect both man and numerous mammalian species resulting in morbidity and mortality. Leptospira interrogans is a pathogenic species that cause leptospirosis while L. biflexa is nonpathogenic. Leptospirosis has worldwide distribution due to the large spectrum of mammalian hosts that harbor and excrete the agent from their renal tubules. The central point on the epidemiology of leptospirosis is the state of the renal carrier, the animal that has its renal tubules colonized by leptospirae, which in turn are excreted in the urine infecting the environment. Infection in domestic animals and wildlife can lead to economic loss and pose a potential spread to the communities. The disease can be directly transmitted through contact with secretions, blood or urine of infected animals, or indirectly through water contaminated mainly with urine of reservoir animals. Leptospirae penetrate intact mucous membrane of the mouth, nose or eyes or abraded, scratched or water softened skin and multiply rapidly after entering the vascular system, spread and further replicate in many tissues including kidney, liver, spleen, central nervous system, eye and genital tract. In Ethiopia leptospirosis is a relatively unknown disease although already reported to occur in domestic animals. The disease is characterized by a broad range of clinical signs which can be presented as acute, sub-acute or chronic. Leptospirosis can be treated by antibiotics such as tetracycline, penicillin, doxycycline, streptomycin and erythromycin, while prevention is characterized by sanitary control and decrease in the risk of infection occurring due to contact with contaminated environments, infected wild animals as well as with synanthropic animals and rodents. Elimination of the carrier state, control of rodents in kennels, maintenance of environmental condition to discourage bacterial survival and isolation of infected animal need to be under taken in order to prevent the disease. Leptospirosis has been recognized as a re-emerging global public health problem due to the increased incidence in both developing and developed countries.
References
Adler, B. and de la Peña Moctezuma, A., 2010. Leptospira and leptospirosis. Veterinary microbiology, 140 (3-4), pp.287-296.
Agampodi, S., Kodituwakku, M., Palihawadana, P., Ginige, S., Jayasinghe, W., Sivasothy, A., Wijesinghe, R., 2013. Risk Factors and Reservoir Species for Leptospirosis in Sri Lanka Principal Investigators: South Asia Regional One Health Symposium 2013.
Aguiar, D.M., Gennari, S.M., Cavalcante, G.T., Labruna, M.B., Vasconcellos, S.A., Rodrigues, A.A., Moraes, Z.M. and Camargo, L., 2006. Seroprevalence of Leptospira spp in cattle from Monte Negro municipality, western Amazon. Pesquisa Veterinária Brasileira, 26 (2), pp.102-104.
Ahmad, S., Shah, S. & Ahmad, F., 2005. Laboratory diagnosis of leptospirosis. Journal of Post graduate Medical, 51: 195-200.
Annual Report 2002/2003, Wonji Hospital.
Anwar, K., Naveed Khan, N. and Mujtaba, M., 2013. Seroprevalence of leptospirosis in aborted dairy cattle in Peshawar district suburb, Khyber Pakhtunkhwa Pakistan. International Journal of Current Microbiology and Applied Science, 2 (8), 73-78.
Azócar-Aedo, L., Smits, H.L. and Monti, G., 2014. Leptospirosis in dogs and cats: epidemiology, clinical disease, zoonotic implications and prevention. Archivos de medicina veterinária, 46 (3), pp.337-348.
Barragan, V., Olivas, S., Keim, P. and Pearson, T., 2017. Critical Knowledge Gaps in Our Understanding of Environmental Cycling and Transmission of Leptospira spp. Applied and Environmental Microbiology, 83 (19), pp.e01190-1197.
Bharti, A.R., Nally, J.E., Ricaldi, J.N., Matthias, M.A., Diaz, M.M., Lovett, M.A., Levett, P.N., Gilman, R.H., Willig, M.R., Gotuzzo, E. and Vinetz, J.M., 2003. Leptospirosis: a zoonotic disease of global importance. The Lancet infectious diseases, 3 (12), pp.757-771.
Bryan, H.M., Darimont, C.T., Paquet, P.C., Ellis, J.A., Goji, N., Gouix, M. and Smits, J.E., 2011. Exposure to infectious agents in dogs in remote coastal British Columbia: Possible sentinels of diseases in wildlife and humans. Canadian journal of veterinary research, 75 (1), 11-17.
Cárdenas, N.C., Infante, G.P., Pacheco, D.A.R., Diaz, J.P.D., Wagner, D.C.M., Dias, R.A., Neto, J.S.F., Amaku, M., Vargas-Pinto, P., Polo, L. and Grisi-Filho, J.H.H., 2018. Seroprevalence of Leptospira spp infection and its risk factors among domestic dogs in Bogotá, Colombia. Veterinary and Animal Science, 6, pp.64-68.
Colagross-Schouten, A.M., Mazet, J.A., Gulland, F.M., Miller, M.A. and Hietala, S., 2002. Diagnosis and seroprevalence of leptospirosis in California sea lions from coastal California. Journal of Wildlife Diseases, 38 (1), 7-17.
Colegrove, K.M., Lowenstine, L.J. and Gulland, F.M., 2005. Leptospirosis in northern elephant seals (Mirounga angustirostris) stranded along the California coast. Journal of Wildlife Diseases, 41(2), 426-430.
Craig, E., J.E Greene, Sykes, A.B. Cathy and K. Hartmann, 2006. Infectious disease of the dog and cat. 3rd edition, Canada, Saunders, pp: 402-417.
De Vries, S.G., Visser, B.J., Nagel, I.M., Goris, M.G., Hartskeerl, R.A. and Grobusch, M.P., 2014. Leptospirosis in Sub-Saharan Africa: a systematic review. International Journal of Infectious Diseases, 28, 47-64.
Devishree, R.A., 2015. Management of leptospirosis: A short review. Journal of Pharmaceutical Sciences and Research, 7 (9), 759.
Divers T. Leptospirosis in ruminants. In: Merck Veterinary Manual. Available from: www.merckvetmanual.com/mvm/generalized_conditions/leptospirosis/ leptospirosis_in_ruminants.html Accessed 27 June 2016.
Doern, G.V., 2000. Detection of selected fastidious bacteria. Clinical infectious diseases, 30 (1), pp.166-173.
Ellis, W.A., 2015. Animal leptospirosis. In Leptospira and leptospirosis (pp. 99-137). Springer, Berlin, Heidelberg.
Eshetu, Y., K. Simone, M. Tsehaynesh, W. Dawit, N. Bethelehem, G. Neway, D. Belachew and J. Eduard, 2004. Human leptospirosis, in Ethiopia: a pilot study in Wonji Hospital, Ethiopian Journal of Health Development., 18: 48-51.
Eslabão, M.R., Dellagostin, O.A. and Cerqueira, G.M., 2010. LepBank: A Leptospira sequence repository and a portal for phylogenetic studies. Infection, Genetics and Evolution, 10 (4), pp.586-590.
Fentahun, T. and Alemayehu, M., 2012. Leptospirosis and its public health significance: a review. European Journal of Applied Sciences, 4 (6): 238-44.
Freitas, J.C.D., Silva, F.G.D., Oliveira, R.C.D., Delbem, Á.C.B., Müller, E.E., Alves, L.A. and Teles, P.S., 2004. Isolation of Leptospira spp from dogs, bovine and swine naturally infected. Ciência rural, 34 (3), pp.853-856.
Goarant, C., 2016. Leptospirosis: risk factors and management challenges in developing countries. Research and reports in tropical medicine, 7, p.49.
Goldstein, R.E., 2010. Canine leptospirosis. Veterinary Clinics: Small Animal Practice, 40 (6), pp.1091-1101.
Greenlee, J.J., Bolin, C.A., Alt, D.P., Cheville, N.F. and Andreasen, C.B., 2004. Clinical and pathologic comparison of acute leptospirosis in dogs caused by two strains of Leptospira kirschneri serovar grippotyphosa. American journal of veterinary research, 65 (8), 1100-1107.
Hartskeerl, R., Collares-Pereira, M. & Ellis, W. 2011. Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world. Clinical Microbiology and Infection, 17: 494-501.
Himani, D., Suman, M.K. and Mane, B.G., 2013. Epidemiology of leptospirosis: an Indian perspective. Journal of Food borne Zoonotic Diseases, 1 (1), 6-13.
Hirsh,D.C., N.J. Maclachlan and R.L. Waller, 2004. Veterinary Microbiology. 2 ed. USA, Black well pp: 148-152.
Joshi, Y.P., Kim, E.H. and Cheong, H.K., 2017. The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study. BMC infectious diseases, 17 (1), p.406.
Katz, A.R., Buchholz, A.E., Hinson, K., Park, S.Y. and Effler, P.V., 2011. Leptospirosis in hawaii, USA, 1999–2008. Emerging Infectious Diseases, 17 (2), p.221.
Keystone, J.S., Freedman, D.O., Kozarsky, P.E., Connor, B.A. and Nothdurft, H.D., 2012. Travel Medicine E-Book: Expert Consult-Online and Print. Elsevier Health Sciences.
Ko, A., Goarant, C. &Picardeau, M. 2009. Leptospira, the dawn of the molecular genetics era for an emerging zoonotic pathogen. Journal of Nature Reviews Microbiology, 7: 736-47.
Lau, C.L., Smythe, L.D., Craig, S.B. and Weinstein, P., 2010. Climate change, flooding, urbanisation and leptospirosis: fuelling the fire?. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104 (10), pp.631-638.
Lehmann, J.S., Matthias, M.A., Vinetz, J.M. and Fouts, D.E. 2014. Leptospiral pathogenomics. Pathogens 3 (2), 280-308.
Levett, P.N., Morey, R.E., Galloway, R., Steigerwalt, A.G. and Ellis, W.A., 2005. Reclassification of Leptospira parva Hovind-Hougen et al. 1982 as Turneriella parva gen. nov., comb. nov. International journal of systematic and evolutionary microbiology, 55 (4), 1497-1499.
Lilenbaum, W., Varges, R., Brandão, F.Z., Cortez, A., De Souza, S.O., Brandão, P.E., Richtzenhain, L.J. and Vasconcellos, S.A., 2008. Detection of Leptospira spp. in semen and vaginal fluids of goats and sheep by polymerase chain reaction. Theriogenology, 69 (7), pp.837-842.
Loan, H.K., Van Cuong, N., Takhampunya, R., Kiet, B.T., Campbell, J., Them, L.N., Bryant, J.E., Tippayachai, B., Van Hoang, N., Morand, S. and Hien, V.B., 2015. How important are rats as vectors of leptospirosis in the Mekong Delta of Vietnam?. Vector-Borne and Zoonotic Diseases, 15 (1), pp.56-64.
Lucheis, S.B. and Ferreira Jr, R.S., 2011. Ovine leptospirosis in Brazil. Journal of Venomous Animals and Toxins including Tropical Diseases, 17 (4), pp.394-405.
Ma, J., 2004. Smith h, Joseph P, Gilman Rh, Bautista CT, Campos KJ, et al. Environmental exposure and leptospirosis, Peru. Emerging Infectious Disease 10 (6), pp.1016-22.
Marquez, A., Djelouadji, Z., Lattard, V. and Kodjo, A., 2017. Overview of laboratory methods to diagnose Leptospirosis and to identify and to type leptospires. Int Microbiol, 20 (4), pp.184-193.
Martins, G. and Lilenbaum, W., 2014. Leptospirosis in sheep and goats under tropical conditions. Tropical animal health and production, 46 (1), pp.11-17.
Matthias, M.A. and Levett, P.N., 2002. Leptospiral carriage by mice and mongooses on the island of Barbados. The West Indian Medical Journal, 51 (1), pp.10-13.
McBride, A.J., Athanazio, D.A., Reis, M.G. and Ko, A.I. 2005. Leptospirosis. Current Opinion Infectious Disease 18 (5), 376-386.
Meites, E., M.T. Jay, S. Deresinski, W.J. Shieh, S.R. Zaki, L. Tompkins and D.S. Smith, 2004. Reemerging leptospirosis, California. Emerging Infectious Disease, 10 (3): 406-12.
Melo, L.D.S.S., de Castro, M.B., Leite, R.C., Moreira, É.C. and de Melo, C.B., 2010. Principais aspectos da infecção por Leptospira sp em ovinos. Ciência Rural, 40 (5), pp.1235-1241.
Miller, M.D., Annis, K.M., Lappin, M.R. and Lunn, K.F., 2011. Variability in results of the microscopic agglutination test in dogs with clinical leptospirosis and dogs vaccinated against leptospirosis. Journal of veterinary internal medicine, 25 (3), 426-432.
Mohammed, H., Nozha, C., Hakim, K., Abdelaziz, F. and Rekia, B., 2011. Leptospira: morphology, classification and pathogenesis. Journal of Bacteriol Parasitology, 2 (06).
Monahan, A.M., Miller, I.S. and Nally, J.E., 2009. Leptospirosis: risks during recreational activities. Journal of applied microbiology, 107 (3), 707-716.
Mwachui, M.A., Crump, L., Hartskeerl, R., Zinsstag, J. and Hattendorf, J., 2015. Environmental and behavioural determinants of leptospirosis transmission: a systematic review. PLoS neglected tropical diseases, 9 (9), p.e0003843.
Nally, J.E., Arent, Z., Bayles, D.O., Hornsby, R.L., Gilmore, C., Regan, S., McDevitt, A.D., Yearsley, J., Fanning, S. and McMahon, B.J., 2016. Emerging infectious disease implications of invasive mammalian species: the greater white-toothed shrew (Crocidura russula) is associated with a novel serovar of pathogenic Leptospira in Ireland. PLoS neglected tropical diseases, 10 (12), p.e0005174.
Narayan, A., 2009. Paniker. Text Book of Microbiology, 8th edition, 382-387
Palaniappan, R.U., Ramanujam, S. and Chang, Y.F., 2007. Leptospirosis: pathogenesis, immunity, and diagnosis. Current opinion in infectious diseases, 20 (3), pp.284-292.
Pavli, A. and Maltezou, H.C., 2008. Travel‐acquired leptospirosis. Journal of travel medicine, 15 (6), pp.447-453.
Petrakovsky, J., Bianchi, A., Fisun, H., Najera, P. & Pereira, M. 2014. Animal Leptospirosis in Latin America and the Caribbean Countries, Reported Outbreaks and Literature Review (2002-2014), International journal of Environmental Research and Public Health, 11 (10): 10770-10789.
Prevention (US) and National Association of State Public Health Veterinarians (US), 2005. Compendium of measures to prevent disease associated with animals in public settings, 2005 (Vol. 54). US Dept. of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention.
Radostits, O.M., C.C. Gay, K.W. Hinclcliff and P.O. Constable, 2007. Veterinary medicine: A text book of the disease of cattle, sheep, pigs, goat and horses, 10 ed. London, Saunders, pp: 1094-1110.
Radostits, O.M., Gay, C.C., Hinchcliff, K.W. and Constable, P.D. eds., 2006. Veterinary Medicine E-Book: A textbook of the diseases of cattle, horses, sheep, pigs and goats. Elsevier Health Sciences.
Regmi, L., Pandey, K., Malla, M., Khanal, S. and Pandey, B.D., 2017. Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal. BMC infectious diseases, 17 (1), p.628.
Ren, S.X., Fu, G., Jiang, X.G., Zeng, R., Miao, Y.G., Xu, H., Zhang, Y.X., Xiong, H., Lu, G., Lu, L.F. and Jiang, H.Q., 2003. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature, 422 (6934), p.888.
Ressner, R.A., Griffith, M.E., Beckius, M.L., Pimentel, G., Miller, R.S., Mende, K., Fraser, S.L., Galloway, R.L., Hospenthal, D.R. and Murray, C.K., 2008. Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. Antimicrobial agents and chemotherapy, 52 (8), pp.2750-2754.
Segura, E.R., Ganoza, C.A., Campos, K., Ricaldi, J.N., Torres, S., Silva, H., Céspedes, M.J., Matthias, M.A., Swancutt, M.A., Linán, R.L. and Gotuzzo, E., 2005. Clinical spectrum of pulmonary involvement in leptospirosis in a region of endemicity, with quantification of leptospiral burden. Clinical infectious diseases, 40 (3), pp.343-351.
Sharma, M. and A. Yadav, 2008. Leptospirosis epidemiology, diagnosis and control, Journal of Infectious Disease and Antimicrobial Agents, 25 (2): 93-103.
Spickler, A.R. and Leedom Larson, K.R., 2013. Leptospirosis (Factsheet). Iowa State University.
Subharat, S., Wilson, P.R., Heuer, C., Collins-Emerson, J.M., Smythe, L.D., Dohnt, M.F., Craig, S.B. and Burns, M.A., 2011. Serosurvey of leptospirosis and investigation of a possible novel serovar Arborea in farmed deer in New Zealand. New Zealand veterinary journal, 59 (3), 139-142.
Sykes, J.E., Hartmann, K., Lunn, K.F., Moore, G.E., Stoddard, R.A. and Goldstein, R.E., 2011. 2010 ACVIM small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention. Journal of veterinary internal medicine, 25 (1), 1-13.
Tangkanakul, W., Smits, H.L., Jatanasen, S. and Ashford, D.A., 2005. Leptospirosis: an emerging health problem in Thailand. Southeast Asian Journal of Tropical Medicine & Public Health, 36 (2), 281-288.
Thayaparan, S., Robertson, I., Fairuz, A., Suut, L. & Abdullah, M. 2013. Leptospirosis, an emerging zoonotic disease in Malaysia. Malaysian Journal of Pathology, 35 (2): 123-32.
Tilahun, Z., Reta, D. and Simenew, K., 2013. Global epidemiological overview of leptospirosis. Int J Microbiol Res, 4 (1), 9-15.
Toyokawa, T., Ohnishi, M. and Koizumi, N., 2011. Diagnosis of acute leptospirosis. Expert review of anti-infective therapy, 9 (1), pp.111-121.
Tsegaye, K., Potts, A., Akililu, N., Lötter, C. and Gummow, B. 2016. Circulating serovars of Leptospira in cart horses of central and southern Ethiopia and associated risk factors. Journal of Preventive Veterinary Medicine, 125:106-115.
Van, C.D., Doungchawee, G., Suttiprapa, S., Arimatsu, Y., Kaewkes, S. and Sripa, B., 2017. Association between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailand. Parasitology international, 66 (4), pp.503-509.
Vanasco, N.B., Schmeling, M.F., Lottersberger, J., Costa, F., Ko, A.I. and Tarabla, H.D., 2008. Clinical characteristics and risk factors of human leptospirosis in Argentina (1999–2005). Acta Tropica, 107 (3), pp.255-258.
Verma, A., Stevenson, B. and Adler, B., 2013. Leptospirosis in horses. Veterinary microbiology, 167 (1-2), pp.61-66.
Vijayachari, P., Sugunan, A.P. and Shriram, A.N., 2008. Leptospirosis: an emerging global public health problem. Journal of biosciences, 33 (4), 557-569.
Wang, Z., Jin, L. and Węgrzyn, A., 2007. Leptospirosis vaccines. Microbial cell factories, 6 (1), p.39.
Wasinski, B. and Dutkiewicz, J., 2013. Leptospirosis-current risk factors connected with human activity and the environment. Annals of Agricultural and Environmental Medicine, 20 (2).
Yadeta, W., Bashahun, G.M. and Abdela, N., 2016. Leptospirosis in Animal and its Public Health Implications: A Review. World Applied Science Journal, 34 (6), 845-853.
Yan, W., Faisal, S.M., McDonough, S.P., Divers, T.J., Barr, S.C., Chang, C.F., Pan, M.J. and Chang, Y.F., 2009. Immunogenicity and protective efficacy of recombinant Leptospira immunoglobulin-like protein B (rLigB) in a hamster challenge model. Microbes and infection, 11 (2), pp.230-237.
Yimer, E., Koopman, S., Messele, T., Wolday, D., Newayeselassie, B., Gessese, N., Degefe, B. and Sandres, E.J., 2004. Human leptospirosis in Ethiopia: a pilot study in Wonji. Ethiopian Journal of Health Development, 18 (1), 48-51.
Zacarias, F., Vasconcellos, S., Anzai, E., Giraldi, N., Freitas, J. & Hartskeerl, R. 2008. Isolation of leptospira serovars Canicola and Copenhagen from cattle urine in the state of Parana, Brazil. Brazilian, Journal of Microbiology, 39 (4): 744-748.
Zavitsanou, A. and Babatsikou, F., 2008. Leptospirosis: epidemiology and preventive measures. Health Science Journal, 2 (2).
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