On Patients with Colorectal Cancer

Associations, prognosis, survival and effects of therapy performed in the intestinal microbiota

Authors

DOI:

https://doi.org/10.56226/83

Keywords:

cancer, cancer management, survival , therapy, healthcare management

Abstract

Abstract:
Background: Colorectal cancer (CRC) is one of the most common cancers in the Western world, with approximately 1.2 million people diagnosed worldwide each year. Most CRCs are sporadic, resulting from chromosome instability and dysplasia of adenomas to carcinomas. At the same time, the hereditary syndromes of familial adenomatous polyposis (FAP) and hereditary nonpolyposis colpos (HNPCC) arise due to germline mutations in the APC gene and the microsatellite instability pathway. Dysbiosis and associated chronic inflammation have previously been implicated in inflammatory bowel disease, irritable bowel syndrome, and type 2 diabetes mellitus. They are now known to facilitate carcinogenesis in CRC through genetic and epigenetic mechanisms. The dysbiotic bacterium primarily implicated in CRC is Fusobacterium nucleatum, associated with microsatellite instability and lymph node metastasis in clinical trials. Recent clinical studies have also suggested that they may affect prognosis, which, if established, could potentially signal a new frontier in the diagnosis, evaluation and therapeutic management of CRC. Objectives: To systematically review the literature to gather evidence investigating the associations between gut microbiota and CRC, colorectal adenomas, CRC tumour site, CRC stage, prognosis and survival, and the effect of current therapy performed for the treatment of CRC.

Methodology: A systematic review of the published literature. Results: 53 studies were considered relevant for inclusion, covering a total of 5167 CRC patients, of which 3754 were tested through mucosal tissue samples, 1072 through stool samples and 341 through a combination.

Conclusion: There is a significant association between gut microbiome and CRC, with emphasis on Fusobacterium (genus) and F. nucleatum (species). This association appears to exist more in advanced stages of the tumour and/or adenoma and is often associated with worse prognosis and shorter survival.
Keywords: Colorectal cancer, familial adenomatous polyposis, Fusobacterium nucleatum, intestinal microbiota

References

Albenberg, L., Esipova, T. V., Judge, C. P., Bittinger, K., Chen, J., Laughlin, A., Grunberg, S., Baldassano, R. N., Lewis, J. D., Li, H., Thom, S. R., Bushman, F. D., Vinogradov, S. A., & Wu, G. D. (2014). Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology, 147(5), 1055–63.e8. https://doi.org/10.1053/j.gastro.2014.07.020.

Ahn, J., Sinha, R., Pei, Z., Dominianni, C., Wu, J., Shi, J., Goedert, J. J., Hayes, R. B., & Yang, L. (2013). Human gut microbiome and risk for colorectal cancer. Journal of the National Cancer Institute, 105(24), 1907–1911. https://doi.org/10.1093/jnci/djt300

Allali, I., Delgado, S., Marron, P. I., Astudillo, A., Yeh, J. J., Ghazal, H., Amzazi, S., Keku, T., & Azcarate-Peril, M. A. (2015). Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain. Gut microbes, 6(3), 161–172. https://doi.org/10.1080/19490976.2015.1039223.

American……….

Amitay, E. L., Werner, S., Vital, M., Pieper, D. H., Höfler, D., Gierse, I. J., Butt, J., Balavarca, Y., Cuk, K., & Brenner, H. (2017). Fusobacterium and colorectal cancer: causal factor or passenger? Results from a large colorectal cancer screening study. Carcinogenesis, 38(8), 781–788. https://doi.org/10.1093/carcin/bgx053.

Arnold, M., Sierra, M. S., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2017). Global patterns and trends in colorectal cancer incidence and mortality. Gut, 66(4), 683–691. https://doi.org/10.1136/gutjnl-2015-310912

Bernie T, Les I, Paul G, Jan K, David W, Chris S. A systematic review of the effects of screening for colorectal cancer using the faecal occult blood test, Hemoccult. BMJ. 1998 Aug 29;317(7158):559–65

Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E. M., Lazarev, M. G., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., Platz, E. A., Pardoll, D. M., & Sears, C. L. (2015). The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(2), 208–215. https://doi.org/10.1093/cid/ciu787.

Borges-Canha, M., Portela-Cidade, J. P., Dinis-Ribeiro, M., Leite-Moreira, A. F., & Pimentel-Nunes, P. (2015). Role of colonic microbiota in colorectal carcinogenesis: a systematic review. Revista espanola de enfermedades digestivas, 107(11), 659–671. https://doi.org/10.17235/reed.2015.3830/2015.

Bowel cancer incidence statistics [Internet]. Cancer Research UK. 2015 [cited 2018 Apr 29]. Available from: http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/bowel-cancer/incidence

Brenner, H., Kloor, M., & Pox, C. P. (2014). Colorectal cancer. Lancet (London, England), 383(9927), 1490–1502. https://doi.org/10.1016/S0140-6736(13)61649-9

Burns, M. B., Lynch, J., Starr, T. K., Knights, D., & Blekhman, R. (2015). Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment. Genome medicine, 7(1), 55. https://doi.org/10.1186/s13073-015-0177-8.

Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., & Holt, R. A. (2012). Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome research, 22(2), 299–306. https://doi.org/10.1101/gr.126516.111.

Chang, L., Chang, M., Chang, H. M., & Chang, F. (2017). Expending Role of Microsatellite Instability in Diagnosis and Treatment of Colorectal Cancers. Journal of gastrointestinal cancer, 48(4), 305–313. https://doi.org/10.1007/s12029-017-9991-0.

Chen, W., Liu, F., Ling, Z., Tong, X., & Xiang, C. (2012). Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer. PloS one, 7(6), e39743. https://doi.org/10.1371/journal.pone.0039743

Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., Stein, E., Vadivelu, J., Roslani, A. C., Malik, A. A., Wanyiri, J. W., Goh, K. L., Thevambiga, I., Fu, K., Wan, F., Llosa, N., … Sears, C. L. (2014). Microbiota organization is a distinct feature of proximal colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America, 111(51), 18321–18326. https://doi.org/10.1073/pnas.1406199111

Eid, N., Enani, S., Walton, G., Corona, G., Costabile, A., Gibson, G., Rowland, I., & Spencer, J. P. (2014). The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. Journal of nutritional science, 3, e46. https://doi.org/10.1017/jns.2014.16.

Fan, P., Li, L., Rezaei, A., Eslamfam, S., Che, D., & Ma, X. (2015). Metabolites of Dietary Protein and Peptides by Intestinal Microbes and their Impacts on Gut. Current protein & peptide science, 16(7), 646–654. https://doi.org/10.2174/1389203716666150630133657

Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., Su, L., Li, X., Li, X., Li, J., Xiao, L., Huber-Schönauer, U., Niederseer, D., Xu, X., Al-Aama, J. Y., Yang, H., … Wang, J. (2015). Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nature communications, 6, 6528. https://doi.org/10.1038/ncomms7528.

Flanagan, L., Schmid, J., Ebert, M., Soucek, P., Kunicka, T., Liska, V., Bruha, J., Neary, P., Dezeeuw, N., Tommasino, M., Jenab, M., Prehn, J. H., & Hughes, D. J. (2014). Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 33(8), 1381–1390. https://doi.org/10.1007/s10096-014-2081-3.

Flemer, B., Lynch, D. B., Brown, J. M., Jeffery, I. B., Ryan, F. J., Claesson, M. J., O'Riordain, M., Shanahan, F., & O'Toole, P. W. (2017). Tumour-associated and non-tumour-associated microbiota in colorectal cancer. Gut, 66(4), 633–643. https://doi.org/10.1136/gutjnl-2015-309595

Flemer, B., Warren, R. D., Barrett, M. P., Cisek, K., Das, A., Jeffery, I. B., Hurley, E., O'Riordain, M., Shanahan, F., & O'Toole, P. W. (2018). The oral microbiota in colorectal cancer is distinctive and predictive. Gut, 67(8), 1454–1463. https://doi.org/10.1136/gutjnl-2017-314814.

Gaines, S., Shao, C., Hyman, N., & Alverdy, J. C. (2018). Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery. The British journal of surgery, 105(2), e131–e141. https://doi.org/10.1002/bjs.10760.

Gao Z, Guo B, Gao R, Zhu Q, Qin H. Microbiota disbiosis is associated with colorectal cancer. Front Microbiol [Internet]. 2015 [cited 2018 Mar 27];6. Available from: https://www.frontiersin.org/articles/10.3389/fmicb.2015.00020/full

Gharbia, S. E., Shah, H. N., Lawson, P. A., & Haapasalo, M. (1990). Distribution and frequency of Fusobacterium nucleatum subspecies in the human oral cavity. Oral microbiology and immunology, 5(6), 324–327. https://doi.org/10.1111/j.1399-302x.1990.tb00434.x

Gralka, E., Luchinat, C., Tenori, L., Ernst, B., Thurnheer, M., & Schultes, B. (2015). Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner. The American journal of clinical nutrition, 102(6), 1313–1322. https://doi.org/10.3945/ajcn.115.110536.

Haggar, F. A., & Boushey, R. P. (2009). Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clinics in colon and rectal surgery, 22(4), 191–197. https://doi.org/10.1055/s-0029-1242458

Hashemi Goradel, N., Heidarzadeh, S., Jahangiri, S., Farhood, B., Mortezaee, K., Khanlarkhani, N., & Negahdari, B. (2019). Fusobacterium nucleatum and colorectal cancer: A mechanistic overview. Journal of cellular physiology, 234(3), 2337–2344. https://doi.org/10.1002/jcp.27250.

Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 [Updated March 2011] The Cochrane Collaboration [Internet]. 2011 [cited 2018 Apr 18]. Available from: http://handbook-5-1.cochrane.org/

Hussan, H., Clinton, S. K., Roberts, K., & Bailey, M. T. (2017). Fusobacterium's link to colorectal neoplasia sequenced: A systematic review and future insights. World journal of gastroenterology, 23(48), 8626–8650. https://doi.org/10.3748/wjg.v23.i48.8626.

ISRCTN - ISRCTN13334746: IntAct- IFA to prevent anastomotic leak in rectal cancer surgery [Internet]. [cited 2018 Apr 30]. Available from: https://www.isrctn.com/ISRCTN13334746?q=&filters=conditionCategory:Cancer&sort=&offset=5&totalResults=1937&page=1&pageSize=10&searchType=basic-search

Jalanka, J., Salonen, A., Salojärvi, J., Ritari, J., Immonen, O., Marciani, L., Gowland, P., Hoad, C., Garsed, K., Lam, C., Palva, A., Spiller, R. C., & de Vos, W. M. (2015). Effects of bowel cleansing on the intestinal microbiota. Gut, 64(10), 1562–1568. https://doi.org/10.1136/gutjnl-2014-307240.

Jurjus, A., Eid, A., Al Kattar, S., Zeenny, M. N., Gerges-Geagea, A., Haydar, H., Hilal, A., Oueidat, D., Matar, M., Tawilah, J., Hussein, I. H., Schembri-Wismayer, P., Cappello, F., Tomasello, G., Leone, A., & Jurjus, R. A. (2015). Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links. BBA clinical, 5, 16–24. https://doi.org/10.1016/j.bbacli.2015.11.002.

Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., El-Omar, E. M., Brenner, D., Fuchs, C. S., Meyerson, M., & Garrett, W. S. (2013). Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell host & microbe, 14(2), 207–215. https://doi.org/10.1016/j.chom.2013.07.007

Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., Baselga, J., Liu, C., Shivdasani, R. A., Ogino, S., Birren, B. W., Huttenhower, C., Garrett, W. S., & Meyerson, M. (2012). Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome research, 22(2), 292–298. https://doi.org/10.1101/gr.126573.111

Kunzmann, A. T., Proença, M. A., Jordao, H. W., Jiraskova, K., Schneiderova, M., Levy, M., Liska, V., Buchler, T., Vodickova, L., Vymetalkova, V., Silva, A. E., Vodicka, P., & Hughes, D. J. (2019). Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 38(10), 1891–1899. https://doi.org/10.1007/s10096-019-03649-1

Liang JQ, Chiu J, Chen Y, Huang Y, Higashimori A, Fang J-Y, et al. Fecal Bacteria Act as Novel Biomarkers for Non-Invasive Diagnosis of Colorectal Cancer. Clin Cancer Res [Internet]. 2016 Jan 1; Available from: http://clincancerres.aacrjournals.org/content/early/2016/10/01/1078-0432.CCR-16-1599.abstract

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (Clinical research ed.), 339, b2700. https://doi.org/10.1136/bmj.b2700

Littman, D. R., & Pamer, E. G. (2011). Role of the commensal microbiota in normal and pathogenic host immune responses. Cell host & microbe, 10(4), 311–323. https://doi.org/10.1016/j.chom.2011.10.004.

Luo, K., Zhang, Y., Xv, C., Ji, J., Lou, G., Guo, X., Chen, M., Zhang, Y., Wei, H., Guo, M., Huang, R., & Yu, S. (2019). Fusobacterium nucleatum, the communication with colorectal cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 116, 108988. https://doi.org/10.1016/j.biopha.2019.108988

Malago J. J. (2015). Contribution of microbiota to the intestinal physicochemical barrier. Beneficial microbes, 6(3), 295–311. https://doi.org/10.3920/BM2014.0041

Marchesi, J. R., Dutilh, B. E., Hall, N., Peters, W. H., Roelofs, R., Boleij, A., & Tjalsma, H. (2011). Towards the human colorectal cancer microbiome. PloS one, 6(5), e20447. https://doi.org/10.1371/journal.pone.0020447

McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013). Fusobacterium is associated with colorectal adenomas. PloS one, 8(1), e53653. https://doi.org/10.1371/journal.pone.0053653

Mima, K., Cao, Y., Chan, A. T., Qian, Z. R., Nowak, J. A., Masugi, Y., Shi, Y., Song, M., da Silva, A., Gu, M., Li, W., Hamada, T., Kosumi, K., Hanyuda, A., Liu, L., Kostic, A. D., Giannakis, M., Bullman, S., Brennan, C. A., Milner, D. A., … Ogino, S. (2016). Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location. Clinical and translational gastroenterology, 7(11), e200. https://doi.org/10.1038/ctg.2016.53.

Mima, K., Nishihara, R., Qian, Z. R., Cao, Y., Sukawa, Y., Nowak, J. A., Yang, J., Dou, R., Masugi, Y., Song, M., Kostic, A. D., Giannakis, M., Bullman, S., Milner, D. A., Baba, H., Giovannucci, E. L., Garraway, L. A., Freeman, G. J., Dranoff, G., Garrett, W. S., … Ogino, S. (2016). Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut, 65(12), 1973–1980. https://doi.org/10.1136/gutjnl-2015-310101

Monda, V., Villano, I., Messina, A., Valenzano, A., Esposito, T., Moscatelli, F., Viggiano, A., Cibelli, G., Chieffi, S., Monda, M., & Messina, G. (2017). Exercise Modifies the Gut Microbiota with Positive Health Effects. Oxidative medicine and cellular longevity, 2017, 3831972. https://doi.org/10.1155/2017/3831972

Moreno, C. C., Mittal, P. K., Sullivan, P. S., Rutherford, R., Staley, C. A., Cardona, K., Hawk, N. N., Dixon, W. T., Kitajima, H. D., Kang, J., Small, W. C., Oshinski, J., & Votaw, J. R. (2016). Colorectal Cancer Initial Diagnosis: Screening Colonoscopy, Diagnostic Colonoscopy, or Emergent Surgery, and Tumor Stage and Size at Initial Presentation. Clinical colorectal cancer, 15(1), 67–73. https://doi.org/10.1016/j.clcc.2015.07.004.

Nakatsu G, Li X, Zhou H, Sheng J, Wong SH, Wu WKK, et al. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun. 2015 Oct 30;6:8727.

Nosho, K., Sukawa, Y., Adachi, Y., Ito, M., Mitsuhashi, K., Kurihara, H., Kanno, S., Yamamoto, I., Ishigami, K., Igarashi, H., Maruyama, R., Imai, K., Yamamoto, H., & Shinomura, Y. (2016). Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World journal of gastroenterology, 22(2), 557–566. https://doi.org/10.3748/wjg.v22.i2.557

Rivière A, Selak M, Lantin D, Leroy F, Vuyst LD. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Front Microbiol [Internet]. 2016 [cited 2018 Apr 29];7. Available from: /pmc/articles/PMC4923077/

Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., Shilo, S., Lador, D., Vila, A. V., Zmora, N., Pevsner-Fischer, M., Israeli, D., Kosower, N., Malka, G., Wolf, B. C., Avnit-Sagi, T., … Segal, E. (2018). Environment dominates over host genetics in shaping human gut microbiota. Nature, 555(7695), 210–215. https://doi.org/10.1038/nature25973

Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013). Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell host & microbe, 14(2), 195–206. https://doi.org/10.1016/j.chom.2013.07.012.

Shenker, B. J., & Datar, S. (1995). Fusobacterium nucleatum inhibits human T-cell activation by arresting cells in the mid-G1 phase of the cell cycle. Infection and immunity, 63(12), 4830–4836. https://doi.org/10.1128/iai.63.12.4830-4836.1995

Siegel RL, Fedewa SA, Anderson WF, Miller KD, Ma J, Rosenberg PS, et al. Colorectal Cancer Incidence Patterns in the United States, 1974–2013. JNCI J Natl Cancer Inst [Internet]. 2017 Aug 1 [cited 2018 Apr 29];109(8). Available from: https://academic.oup.com/jnci/article/109/8/djw322/3053481

Singh, R. K., Chang, H. W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., Bhutani, T., & Liao, W. (2017). Influence of diet on the gut microbiome and implications for human health. Journal of translational medicine, 15(1), 73. https://doi.org/10.1186/s12967-017-1175-y.

Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J. J., Blugeon, S., Bridonneau, C., Furet, J. P., Corthier, G., Grangette, C., Vasquez, N., Pochart, P., Trugnan, G., Thomas, G., Blottière, H. M., Doré, J., Marteau, P., Seksik, P., & Langella, P. (2008). Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proceedings of the National Academy of Sciences of the United States of America, 105(43), 16731–16736. https://doi.org/10.1073/pnas.0804812105

Strum W. B. (2016). Colorectal Adenomas. The New England journal of medicine, 374(11), 1065–1075. https://doi.org/10.1056/NEJMra1513581

Sun, C. H., Li, B. B., Wang, B., Zhao, J., Zhang, X. Y., Li, T. T., Li, W. B., Tang, D., Qiu, M. J., Wang, X. C., Zhu, C. M., & Qian, Z. R. (2019). The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management. Chronic diseases and translational medicine, 5(3), 178–187. https://doi.org/10.1016/j.cdtm.2019.09.001 .

Tahara, T., Yamamoto, E., Suzuki, H., Maruyama, R., Chung, W., Garriga, J., Jelinek, J., Yamano, H. O., Sugai, T., An, B., Shureiqi, I., Toyota, M., Kondo, Y., Estécio, M. R., & Issa, J. P. (2014). Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer research, 74(5), 1311–1318. https://doi.org/10.1158/0008-5472.CAN-13-1865.

Talseth-Palmer B. A. (2017). The genetic basis of colonic adenomatous polyposis syndromes. Hereditary cancer in clinical practice, 15, 5. https://doi.org/10.1186/s13053-017-0065-x.

Towler, B., Irwig, L., Glasziou, P., Kewenter, J., Weller, D., & Silagy, C. (1998). A systematic review of the effects of screening for colorectal cancer using the faecal occult blood test, hemoccult. BMJ (Clinical research ed.), 317(7158), 559–565. https://doi.org/10.1136/bmj.317.7158.559.

Tsoi, H., Chu, E. S. H., Zhang, X., Sheng, J., Nakatsu, G., Ng, S. C., Chan, A. W. H., Chan, F. K. L., Sung, J. J. Y., & Yu, J. (2017). Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. Gastroenterology, 152(6), 1419–1433.e5. https://doi.org/10.1053/j.gastro.2017.01.009

Wang, F., Li, Q., Wang, C., Tang, C., & Li, J. (2012). Dynamic alteration of the colonic microbiota in intestinal ischemia-reperfusion injury. PloS one, 7(7), e42027. https://doi.org/10.1371/journal.pone.0042027.

Wei, Z., Cao, S., Liu, S., Yao, Z., Sun, T., Li, Y., Li, J., Zhang, D., & Zhou, Y. (2016). Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? A pilot study on relevant mechanism. Oncotarget, 7(29), 46158–46172. https://doi.org/10.18632/oncotarget.10064.

Wick, E. C., Rabizadeh, S., Albesiano, E., Wu, X., Wu, S., Chan, J., Rhee, K. J., Ortega, G., Huso, D. L., Pardoll, D., Housseau, F., & Sears, C. L. (2014). Stat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilis. Inflammatory bowel diseases, 20(5), 821–834. https://doi.org/10.1097/MIB.0000000000000019

Wu, S., Lim, K. C., Huang, J., Saidi, R. F., & Sears, C. L. (1998). Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin. Proceedings of the National Academy of Sciences of the United States of America, 95(25), 14979–14984. https://doi.org/10.1073/pnas.95.25.14979

Yamane, L., Scapulatempo-Neto, C., Reis, R. M., & Guimarães, D. P. (2014). Serrated pathway in colorectal carcinogenesis. World journal of gastroenterology, 20(10), 2634–2640. https://doi.org/10.3748/wjg.v20.i10.2634

Yan X, Liu L, Li H, Qin H, Sun Z. Clinical significance of Fusobacterium nucleatum, epithelial-mesenchymal transition, and cancer stem cell markers in stage III/IV colorectal cancer patients [Internet]. OncoTargets and Therapy. 2017 [cited 2018 Mar 26]. Available from: https://www.dovepress.com/clinical-significance-of-fusobacterium-nucleatum-epithelial-mesenchyma-peer-reviewed-article-OTT

Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., Chen, Y., Chen, H., Hong, J., Zou, W., & Fang, J. Y. (2017). Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. Cell, 170(3), 548–563.e16. https://doi.org/10.1016/j.cell.2017.07.008

Yu, Y. N., Yu, T. C., Zhao, H. J., Sun, T. T., Chen, H. M., Chen, H. Y., An, H. F., Weng, Y. R., Yu, J., Li, M., Qin, W. X., Ma, X., Shen, N., Hong, J., & Fang, J. Y. (2015). Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment. Oncotarget, 6(31), 32013–32026. https://doi.org/10.18632/oncotarget.5166.

Xu, K., & Jiang, B. (2017). Analysis of Mucosa-Associated Microbiota in Colorectal Cancer. Medical science monitor : international medical journal of experimental and clinical research, 23, 4422–4430. https://doi.org/10.12659/msm.904220.

Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., Hercog, R., Koch, M., Luciani, A., Mende, D. R., Schneider, M. A., Schrotz-King, P., Tournigand, C., Tran Van Nhieu, J., Yamada, T., Zimmermann, J., … Bork, P. (2014). Potential of fecal microbiota for early-stage detection of colorectal cancer. Molecular systems biology, 10(11), 766. https://doi.org/10.15252/msb.20145645.

Zhou, Y., He, H., Xu, H., Li, Y., Li, Z., Du, Y., He, J., Zhou, Y., Wang, H., & Nie, Y. (2016). Association of oncogenic bacteria with colorectal cancer in South China. Oncotarget, 7(49), 80794–80802. https://doi.org/10.18632/oncotarget.13094

JP, Rogers MAM, Ruffin MT, Schloss PD. The Human Gut Microbiome as a Screening Tool for Colorectal Cancer. Cancer Prev Res (Phila Pa) [Internet]. 2014 Aug 7 [cited 2018 Mar 27]; Available from: http://cancerpreventionresearch.aacrjournals.org/content/early/2014/08/06/1940-6207.CAPR-14-0129

colorectal cancer image

Published

02-12-2024

How to Cite

Kenupp, M. G., Vianna, A., Uyeda, M., & Maluf, G. (2024). On Patients with Colorectal Cancer : Associations, prognosis, survival and effects of therapy performed in the intestinal microbiota. International Healthcare Review (online). https://doi.org/10.56226/83

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