On the Psychological experiences of Hematopoietic stem cell donors

an update on International Evidence


  • Min Tian Department of Nursing, Shandong Provincial Qianfoshan Hospital (The First Affiliated Hospital of Shandong First Medical University), China
  • Xiangmin Li
  • Fengjuan Zhou
  • Yafei Wang
  • Qing Wang
  • Ning Pan
  • Hong Ji




Hematopoietic stem cell,Donor,Psychological experience, stem cells, health psychology


Background: Hematopoietic stem cell (HSC) transplantation using bone marrow and peripheral blood stem cells is a lifesaving treatment for patients with leukemia or other blood disorders. Hematopoietic stem cell donors are afraid of harming themselves by donating and are also under pressure from other relatives. Therefore, it is easy to produce negative emotions such as tension, anxiety, panic, depression and so on during the donation period. Although major physical complications of hematopoietic stem cell donors are uncommon, their psychosocial impact remains relatively unknown.

Methods:The authors undertook a Rapid Literature Review focusing on articles published from 2020 to 2022 thus offering the readers access to most up-to-date evidence concerning the topic. This article, therefore, adopts a narrative review methodology.

Results: A total of 7 articles were identified and scrutinized. Hematopoietic stem cell donors generally suffered from physical and mental discomfort. Factors influencing psychological experiences included donation stage, gender, kinship, and transplant results.

Main Contribution to Evidence-Based Practice: The purpose of this rapid literature review is to identify the most recent evidence and knowledge concerning psychological experiences of hematopoietic stem cell donors, in-depth analysis of the real psychological feelings of hematopoietic stem cell donors, in order to further improve the quality of nursing services, relieve the doubts of hematopoietic stem cell donors and mobilize the motivation of hematopoietic stem cell donors provides a reference.


Aguilera, V., Schaefer, M. R., Parris, K., Long, A., Triplett, B., & Phipps, S. (2022). Psychosocial outcomes of parents in pediatric haploidentical transplant: parental hematopoietic cell donation as a double-edged sword. Bone marrow transplantation, 57(3), 377–383. https://doi.org/10.1038/s41409-021-01547-9

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Gutiérrez-Aguirre, C. H., Jaime-Pérez, J. C., de la Garza-Salazar, F., Guerrero-González, G., Guzmán-López, A., Ruiz-Argüelles, G. J., Gómez-Almaguer, D., & Cantú-Rodríguez, O. G. (2021). Moral Distress: Its Manifestations in Healthy Donors during Peripheral Blood Hematopoietic Stem Cell Harvesting. Transplantation and cellular therapy, 27(10), 853–858. https://doi.org/10.1016/j.jtct.2021.06.005

Kim, M., Kim, T. G., & Beom, S. H. (2020). Physical and Psychological Discomfort Experienced by Hematopoietic Stem-Cell Donors. International journal of environmental research and public health, 17(7), 2316. https://doi.org/10.3390/ijerph17072316

Li, N., GUO, M., YOU, S., & JI, H. (2022). On Patient Readiness for Hospital Discharge: an update on recent Evidence. International Healthcare Review (online). https://doi.org/10.56226/ihr.v1i2.30

Lloyd Williams, D. (2022). On Healthcare Research Priorities in the USA : From Long COVID to Precision Health, what else is new?. International Healthcare Review (online), 1(1). https://doi.org/10.56226/ihr.v1i1.14

Moreira, P. (2022). On New Clinical Research Methods and Technologies: From decentralised designs to Artificial Intelligence. International Healthcare Review (online), 1(1). https://doi.org/10.56226/ihr.v1i1.11

Schaefer, M. R., Aguilera, V., Parris, K., Long, A., Triplett, B., & Phipps, S. (2022). "Giving the gift of life twice": Understanding the lived experiences of parent donors and nondonors in pediatric haploidentical hematopoietic cell transplantation. Pediatric blood & cancer, 69(2), e29480. https://doi.org/10.1002/pbc.29480

Shi, Y., Zhao, X., & Wang, Y. (2022). Exploring parents' experience in the decision-making process for children with haematological diseases receiving haematopoietic stem cell transplantation in China based on genograms. Journal of pediatric nursing, 63, e18–e26. https://doi.org/10.1016/j.pedn.2021.11.005

Switzer, G. E., Bruce, J. G., Kiefer, D. M., Kobusingye, H., Abebe, K. Z., Drexler, R., Besser, R. M., Confer, D. L., Horowitz, M. M., King, R. J., Shaw, B. E., Riches, M., Hayes-Lattin, B., Linenberger, M., Bolwell, B., Rowley, S. D., Litzow, M. R., & Pulsipher, M. A. (2020). Health-Related Quality-of-Life Comparison of Adult Related and Unrelated HSC Donors: An RDSafe Study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 26(12), 2365–2371. https://doi.org/10.1016/j.bbmt.2020.08.016

Zomerdijk, N., Turner, J., Hill, G. R., & Gottlieb, D. (2021). Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(2), 635–644. https://doi.org/10.1007/s00520-020-05520-y

image of stem cells



How to Cite

Tian, M., Li , X., Zhou, F., Wang , Y., Wang, Q., Pan , N., & Ji , H. (2023). On the Psychological experiences of Hematopoietic stem cell donors: an update on International Evidence. International Healthcare Review (online). https://doi.org/10.56226/31



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